Rabu, 31 Mei 2017

examples of corticosteroids drugs

examples of corticosteroids drugs

meredith:hello, everyone, and welcome to cellular healing tv. i’m your host, meredith dykstra, and thisepisode #147. we have our resident cellular healing specialist,dr. daniel pompa, on the line, of course. today, we welcome a very special guest, dr.philip blair. dr. blair is no stranger to cellular healingtv. he’s been on the show twice before, episode84 and episode 90. dr. blair is an expert on cbd oil, or cannabidioloil, and healing properties of this really amazing compound from the hemp plant.

we’ve delved into it a lot before, 84 onthat episode was an overview, and episode 90, we discussed the power of cbd oil andhow it impacts alzheimer’s and different brain conditions. it’s such a hot topic, so we brought dr.blair back on cellular healing tv to delve in a little bit further. we’re going to talk about the ecs today,or the endocannabinoid system, and all the benefits that cbd oil can have on that system. we’re going to delve in a lot more. before jump in, let me tell you guys a littlebit about dr. blair if you’ve missed the

other shows, and then we’re going to delveinto this really exciting topic. colonel philip blair, m.d., is a retired familyphysician recently relocated to the florida space coast, which i guess is no longer correctbecause you’re out in washington state. i’ll have to get the updated file next time. he graduated from west point in 1972, andattended university of miami school of medicine, and trained as a family physician. after retiring from the army in 1996, he managedworkers’ injuries and provided primary care above the arctic circle in alaska, kodiakisland, and newfoundland, canada. in 2000, he became vice president for diseasemanagement at awac incorporated, an insurance

claim management company, where he developeda highly successful interventional approach to chronic kidney disease. in 2011, he formed his own company, consultingfor employer-based health insurers and providing a revolutionary style of chronic disease management,achieving success in over 75% of patients with diabetes, obesity, and metabolic syndrome. in addition, he’s a skilled computer databasedeveloper and instructor for speech recognition software on pc and apple platforms. he also enjoys ballroom dancing and publicspeaking. what a well-rounded guy.

welcome, dr. blair, back to cellular healingtv. dr. blair:meredith, it’s great to be here again. i’ve got such exciting information to share,things that i’ve discovered in my studies and my experience with cannabidiol so reallyexcited to be here, especially after the conference in las vegas where you guys did such a magnificentjob. dr. pompa:you can see all of our doctors that know, and teach, and really participate and practicecellular healing use the cannabidiol. it’s such an amazing cellular product. it’s very part of our system.

we’re excited to gain more information. trust me, all of those doctors, and theirclients, and patients are watching. we’d better bring them some good information,man. i can’t wait to hear it. dr. blair:i was always perplexed by why is it that all of these alternative care – because i’man allopathic. i’m a family physician, and i was trainedthat many of these alternative pathways had really no significant value. they were unproven.

over time, i’ve seen very clearly they arevery effective, and they are healthy. the dietary changes that we’ve been toldin medicine have been wrong. what is it? what has been the transition that makes theseother therapies or how is it that these therapies work when we’re not able to define themin the typical allopathic fashion? why do they work? i wanted to explore that. dr. pompa:exactly, this is information that more people need to hear.

i think that right now, people are hearinga lot about marijuana, whether we legalize it, not legalize it. i think that we could have an easy solutionfor everybody if everybody understood. there are benefits to the thc. however, that’s where most of the debatelies. why, because it causes the psychological,the high, if you will, the part of the brain that we need to keep functioning driving acar or whatever. i think there are some studies showing thatthere are some negatives to thc in higher amounts, what it does to the brain.

however, what we’re talking about todayhas nothing to do with that. what we’re talking about, the cbd, the cannabidiolportion, that’s the portion that hey, this is really what has the greatest health benefits,everything. if we’re going to legalize everything, whichthis is already legalized. this is really where the conversation should. bringing in our listeners, this is what we’retalking about. we’re talking about the part of marijuanathat’s already legal, the part of marijuana that really has the most health benefits. most people don’t get the separation, doc.

maybe we should start there and then backinto the conversation. dr. blair:that’s a really good point. i want to make a clear distinction that we’renot talking about the thc portion, the part that makes you high. we’re talking about the healing portionwhich is in the cannabidiol. that’s what medical marijuana is all about. it contains the cannabidiol in high concentrationsso it can affect those particular healing pathways. that’s very, very important that peopleunderstand that.

when we’re talking about marijuana, we’rereally talking about the cannabis plant. the cannabis plant comes in two varieties. this is simplistic, but we’re talking aboutit comes either as marijuana, or it comes as hemp. hemp is the part that contains the cannabidiol,and it doesn’t contain hardly any of the thc. as a result of some of the legislation andconfusion, the cannabidiol is legal when it comes from imported sources. there are several good companies that areproviding really high-quality cannabidiol

from clean sources that have analysis, thatare transparent, and you get consistent product continually. unfortunately, sometimes in some of the statesthat have legalized marijuana, you get a variable quantity in terms of the mix of what is there. you don’t always get the effect, and thenyou are at risk of getting the high that comes along with thc. so many people don’t want to have anythingto do with that, anything that will cloud their thinking or their thought processes. they definitely want to stay away from thatas well as those patients who have restrictions

in terms of their exposure and are being drugtested on a regular basis, a very good point, daniel. dr. pompa:starting there – as a matter of fact, meredith, you might want to just hold off the one thatwe carry because he did say that there’s a few companies. you don’t have it to hold up? meredith:no, i’m at home. i don’t have it. dr. pompa:we’ll get the name.

there are a few companies that really havea quality supply of the cannabidiol. we have one guaranteed at 8%. there’s no chemicals because you’re right,doc. you have to be very careful in this area ofwhat you actually utilize. meredith, you can just tell him the one thatwe carry, and the name, and how to get it. meredith:it is the elixinol brand that we like to use. i believe it’s 18% cbd in the syringe formthat we have. there is the elixinol syringe, which you canget it. it’s in a liquid form.

there are also tinctures, as well, of thecbd oil. we also have it in capsule form, too. you can get those at revelationcbdoil.com. a quick question just to follow up to it:you were saying a lot of people call in and are wondering if i take this cbd oil, is itgoing to show up on a drug test? dr. blair:we try not to insert ourselves into drug testing area, but the cannabidiol and the elixinolproducts don’t contain any significant amounts of thc. there’s definitely no psychoactive effectin terms of getting high, or feeling drowsy,

or having those particular effects that thccauses. i can’t promise that people won’t in termsof drug testing. i can just tell you that the elixinol doesnot contain any significant amounts of thc, which is the only thing that drug testingtests. dr. pompa:i’ve had a couple people get tested when they’re taking the cbd, and they were fine. my kids are on ski team here in park city. they get tested. they take cbd for obvious benefits.

with that said, let’s now get into the benefits. after we’ve talking about some of thesebenefits and why you, and i, and our doctors feel this is such an important product thatwe all should take – and there’s many reasons why. i want to get to which products. meredith brought up that we have the 18% guaranteedcbd oil straight up. we have a tincture, and we even have pillsso we can give our viewers – because, meredith, we always get that question, too: when touse what. what are these for?

what is that for? we’ll talk a little bit about that, so benefitsand which products to take and when. yours, doc. dr. blair:what i want to do is that recent information has come out about the endocannabinoid system. not very many people really understand thatwe have this complex system within our body that is the homeostatic and the regulatorysystem for all of our other systems. what the evidence is showing now is an amazingamount of disease that is focused really right on the endocannabinoid system.

we can’t say that it’s causal, that thingslike migraines, or irritable bowel syndrome, or fibromyalgia are caused by the endocannabinoidsystem, only that these problems are related to dysfunction or deficiencies in the endocannabinoidsystem. as you look at these other diseases, whetherit’s cancer or it’s ptsd, what we’re seeing is consistent disregulation, discordantelements of the endocannabinoid system that are showing disease models. what we may be dealing with in many of thesecomplex diseases that are so difficult to control, especially the chronic ones, is someperturbation of the endocannabinoid system that causes a dysfunction leading to theseparticular diseases, which is why we’re

encountering some of these problems. dr. pompa:just to back up for our viewers and listeners, the endocannabinoid system. we understand the endocrine system, meaningour hormone system. we understand our cardiovascular system, meaningour heart and blood flow, right? what is the endocannabinoid system? dr. blair:it’s very similar to the endocrine system in the sense that it’s endo, meaning inside,and the cannabinoid. the cannabinoid is the kind of molecule thatactually prompted the discovery of this system

in 1992. we really didn’t even know it existed. since that time, we’ve made connectionswith all of these other different systems. that’s what i want to point out is the endocannabinoidsystem is the interface between the outside and the inside as well as the inside to theoutside in terms of how we manifest ourselves, and our personalities, and our characteristics,and our health. the endocannabinoid system is composed ofligands or agonists that interact with receptors that are on the cell membrane and even inthe nucleus of the cell as well as it includes some of the metabolic factors that degradeas well as synthesize the endocannabinoids

that are circulating within our system. the endocannabinoid system has the –it’slocated in the brain, and in the immune system, and in nerve tissue, but it’s also veryhighly located in the gut. dr. pompa:could you say then it’s a communication network, if you will, helping the body communicatesystem to system? dr. blair:it is, yes, but it even – very interesting. it’s almost like a translator. it’s taking our thoughts and ideas, andit’s translating them into performance, into body functions.

what we’re seeing is that with people whoare stressed out, and anxious, and they’re worried about things, that’s translatinginto dysfunction in different areas probably through this translation function that theendocannabinoid system facilitates. the same thing is true for things like dysbiosis,where we’ve got the wrong bacteria in the gut, that it’s causing problems. that’s actually feeding back to the bodyand to the brain, whether it’s creating depression, or anxiety, or dysfunction, andhealth issues. we have this wonderful communication system,when it’s working properly, that’s great. that’s very healthy, and it allows us torecover.

when it’s not working properly, what doyou do about it? how can you enhance and recover the endocannabinoidsystem? what i want to talk to you about today ishow all of the systems that cellular healing is using is enhancing those endocannabinoids,and it’s restoring the endocannabinoid system so that we get back to normal. we restore ourselves and recover from thosetraumas, from the diseases, from the errors in our dietary, and our environmental issuesthat we’re facing with. dr. pompa:i was just going to say look. everything about health is how our body’scommunicating, whether it’s from bacteria

to cell, cell to cell, system to system. in simple format for our viewers, this iswhat the endocannabinoid system does in so many aspects and probably a lot of aspectswe haven’t even discovered yet. dr. blair:i think that’s a really good point. we’ve only gotten through the tip of theiceberg in terms of what’s going on with this. there are so few people who understand oreven know about the endocannabinoid system, and i’m talking about medical professionalswho don’t even know it’s there, then to realize that it is at the heart of so manyof the other systems, that communication between

the brain and the hormones or the brain, andthe heart, and the neurologic system, all of these interfaces going on here. it’s a little bit like – okay, with hormones,that’s like a sledgehammer. you use this corticosteroids example. they have a tremendous, powerful effect, butit’s a sledgehammer. if you use that too often, you’re goingto destroy other systems that are involved. what we’re dealing with in the endocannabinoidsystem is the fine tuning. it’s the ball-peen hammer that is very focusedin terms of making changes and normalizing the body rather than pushing it off in onedirection that actually can develop other

types of diseases. meredith:i have a question dr. blair. i know you had mentioned that a lot of diseasesthat are manifested today are possibly caused by a deficiency or a dysfunction of the ecs. do we know what is causing this deficiencyor dysfunction of the ecs? dr. pompa:endocannabinoid system. dr. blair:as a result of the different environmental things, whether it’s a toxin, or it’sa lack of exercise, or it’s the wrong foods that we’re taking in, these things are makingchanges in the endocannabinoid system that

are subtle, but over a period of time theywill manifest disease. that’s why diet is so important. that’s why probiotics and prebiotics areso important because, in essence, they are making changes to the endocannabinoid systemand signaling the body to make overall changes. in good health, when we’re doing all thethings that we’re supposed to be doing, whether that’s diet, exercise, meditationand prayer, relaxation techniques, all of those things – that’s great. then we can restore the endocannabinoid system. we’re using those as endocannabinoid enhancers.

when we get to a point where we’re justat too low a level, or we have toxins that are interfering with that recovery, or wehave a major injury, then you’re not going to be able to recover. you’ve got to boost that system. that’s what i see as why we as allied healthprofessions can all work together in terms of recovering the endocannabinoid system andrestoring health to so many individuals. dr. pompa:this is where the cbd oil comes in. how does it balance the system? what does it do?

dr. blair:that’s one part of it because you’ve got the therapies that you know work. i was talking with a chiropractor in australia,and he was lamenting to me that it used to be that osteopathic manipulation was greatand that resolved 90% of the problems. that doesn’t work anymore. the therapies that have been tried and truearen’t working anymore on today’s population. there’s something more going on. what it is, i think that’s open to debateand concerns. there’s lots of evidence for these othertypes of problems, whether it’s in the foods

that we’re taking in, or it’s chlorine,or it’s lead, mercury. all of those things are probably playing arole, but it’s not working anymore those simple therapies. that’s why a combined approach is so veryimportant in terms of restoring the endocannabinoid system. what you do with regard to diet, with regardto sleep, with regard to exercise, those are all very positive and herbal supplementation. you’re enhancing the endocannabinoid system. that’s where the phytocannabinoid cannabidiolreally comes into play because it can work

as an enhancer for the endocannabinoid system,whereas some of these other things are pushing in one direction. it’s the sledgehammer approach. what we want to use is some fine tuning andrestoration rather than pushing the body in one direction only. dr. pompa:let’s talk about it. doc, i know you’ve done so much research. you send us emails all the time about a researcharticle on cannabidiol and alzheimer’s. here’s one on parkinson’s.

we know the research is piling up as far ascbd, cannabidiol, and its impact in these nerve degenerative conditions, depression. i can go down the list. you’ve sent me many different. share with our viewers some of those studiesand some of the effects on some of these conditions. dr. blair:i mentioned three already, about the migraine, and the irritable bowel syndrome, and chronicfatigue syndrome. these syndromes, that’s another word forthings that we don’t know what’s causing it but it has all of these symptoms put together.

they’re all characterized by a central hypersensitivity. the migraine, or the irritable bowel, thechronic fatigue, they all have this central sensitivity to almost anything that they areexposed to. if they get too much of anything or get undertoo much stress, then they manifest worsening disease. these particularly are excellent at characterizingthe endocannabinoid deficiency-type of syndrome. what it comes down is these diseases may bethe first of the endocannabinoid system dysfunction deficiency that can be corrected and can betargeted with the endocannabinoid enhancement therapy that we’re all using.

in other areas like the brain, you mentionedthe alzheimer’s disease. there’s also parkinson’s. there are others. als has been shown. all of these conditions are now showing endocannabinoiddysfunction. that means that either the endocannabinoidhormones are too high, or they’re too low, or the receptors are wonky. they’re just not around in the right concentration. that indicates that it’s really a balancethat’s going on.

it’s not a matter of being too much or toolittle because almost every tissue, every part of the body, behaves differently andreacts differently due to these different levels. instead of trying to control one with pushingthe level higher or lower, it’s a matter of let’s get it back in balance. a lot of the things that we do that are healthy,diet, exercise, sleep, are all important for balancing those and restoring normal. dr. pompa:i think it brings up the obvious question. we always get this question, right meredith,the dosing of it.

how do we dose cbd? do we dose it differently per condition? do we start low? talk about it. we’ve talked in some of the past shows aboutthe dosing of it. that brings us into the conversation of whatproducts. we have the syringe which really gives thehighest punch. then we have the tincture that i’ll oftentimesstart with people who i just want to start slow with.

of course, it has a nice pleasant taste. that helps, too, for the kids. then, of course, we even have the pills. when would we use that? share a little bit from that. dr. blair:let me get to that, but i just want to mention about behavioral diseases like ptsd. there is very clear evidence on pet scansthese people have abnormal cb1 receptor functions and their anandamide levels, or their naturalendocannabinoids, are decreased.

in the area of depression, schizophrenia,these are all showing endocannabinoid dysfunctions, irregularities. the same is true with the gut. the same thing is happening there in inflammatorybowel disease as well as irritable bowel disease. it goes on to the immune system in terms ofthe hyperactivity and the autoimmune diseases as well as the hormones. the hormone functions, the stress hormones,cortisol particularly, is regulated by the endocannabinoid system. that goes into a lot of the drugs that weuse.

we usually think well, we’re using thisdrug. how does that drug work? it turns out that many of those drugs areactually using the endocannabinoid system. things as simple as tylenol, acetaminophen,are using the endocannabinoid system as well as the corticosteroids, and the antidepressants,and the antipsychotics. they’re all going through this particularsystem, but they’re the sledgehammer approach. it’s not a balanced approach. dr. pompa:i can tell you first hand that many of my clients have major pain.

they start taking the cbd, and they noticea difference right away without having to take their pain meds that they were literallystuck on. likewise, you had mentioned the gut conditions. at some point, we always want to try the cbdoil because of the antiinflammatory effect and the balance that it has on the microbiomein the gut. it’s remarkable. just about every condition we’re dealingwith today, there is some gut component. anxiety, sleep, i always reach for cbd inthese areas: anxiety, sleep, gut, pain, go down the list.

you’re right. i’ve experienced it clinically. meredith:personally, it’s really helped me with sleep and any anxiety issues, as well. i notice i had to take an extremely high doseto notice an impact. i don’t know if you could speak to thatin regards that some maybe need a much less dose than others and why that would be. dr. blair:i want to address that in particular because dosing is a particular problem, and understandingthat, and what goes on with it.

i want to get to the concept here of whatcannabidiol, what this phytocannabinoid does differently than the other substances thatare out there that work on the body and the what is that? what we’re seeing with cannabidiol is it’srestoring the endocannabinoid system. it’s rebalancing the number of receptors,the amount of endocannabinoids, as well as working with some of the other cell-to-cellcommunication that is going on. it’s like a medic working on so many ofthese systems, returning them to a normal function. it’s balancing some of the synthetic hormonesto make more of our natural endocannabinoids

as well as decreasing the amount of degradationor the amount of destruction of those enzymes, those substances, so that you’re maintaininglevels. as you do that using the cannabidiol, we’reseeing a restoration of the endocannabinoid system so that it may be that over time, whenwe have enough experience, we can show that as the endocannabinoid system is restored,less and less of the cannabidiol may be required. less and less of those other therapies maybe required because you’re getting the body back into balance. when you talk about, meredith, you mentionedthat some people require more. you’re absolutely right.

i start with a standard dose and recommendabout 15 mg twice a day for most people. that is a really good starting point becausethat allows you to move forward in terms of increasing the dose or to decrease it verynaturally. i like patients to use it according to whattheir needs are because every patient is different. you don’t have to use – it’s not thesame amount of diet, activity. it’s not the same amount of exercise foreverybody. everybody is an individual, and so is truefor the endocannabinoid system and their level of dysfunction. naturally, you want to adjust it to theirparticular needs.

because cannabidiol doesn’t have any, atleast the elixinol product, doesn’t have any significant side effects, or toxicity,or adversity, and there’s no addictive component to it, you use as much as you need to to getto that target symptom that you’re trying to control. if you need to double the dose, you doublethe dose. meredith:does that mean if you need to take a really high dose that your ecs is much less functioningthan normal or does that correlate? dr. blair:it does suggest that, but we don’t have the studies to prove it, in fact.

what i’ve found is that i really haven’thad to go more than 180 to 200 mg of cbd for anybody in order to get the benefits to it. interestingly, many people who get the analgesia,and they get the anti-anxiety, and those other things that go on, or they don’t get thoseparticular things, but they do get the other side benefits. i think what’s unique to the cannabidiolis that it has all these side benefits. we’re always talking about the adversityof the different drugs and substances. you’ve got to watch out for this side effect. the side effects in the sense of these positivebenefits that occur with cannabidiol are quite

remarkable. as you said, meredith and daniel, in termsof sleep, relaxation, and improved healing, what wonderful side benefits that come alongwith it even if it’s not your main topic and target. dr. pompa:probably so much of it is that it has such an amazing anti-inflamatory effect. obviously with that alone, you will affectso many pathways. you had brought up in one of the past showsits effect on the cell membrane. the cell membrane is pivotal to how many differentthings with our health.

this is how you turn bad genes on and off. this is how your cells move things in andout, your receptors to every hormone are on the cell membrane, and yet it has an amazingeffect on the cell membrane, which by the way is my r number two of my five rs, regeneratingthe cell membrane. cbd oil plays a significant role in the membrane. dr. blair:the way that it does that may be in terms of restoring some of those endocannabinoidreceptors on the cell membrane so that the endocannabinoid system can function better. there is even more.

there are receptors that we’ve now identifiedthat are on the nuclear membrane. there are endocannabinoid receptors that arethere. they get transported from the cell wall andthe membrane to the nucleus to trigger epigenetic changes that go on within the cell. that’s very similar to the ketones and howketones function in terms of signaling through the certain receptors that are on the nuclearmembrane. dr. pompa:i have to ask that question because we’ve talked a lot on this show about epigenetics,and for new viewers, we used to think that hey, you have a thyroid condition or diabetesor you got that particular cancer because

your mom or dad had it. we know today that most genetic conditionsare turned on, meaning we trigger these genes of susceptibility. the good news is studies show we can turnthese genes off, right? you talked about ketones. they have the ability to turn things off. stat’s and bruce lipton’s work, who we’vehad on the show, fixing the membrane and how that turns off those genes. are there studies?

you mentioned one that it affects the receptors,the cannabidiol receptors, on the nucleus. that’s where the dna is. are there studies now showing that cbd oilhas an effect on turning bad genes off or good ones on? dr. blair:yes, i think there are some incredible studies that show that it’s working. cannabidiol is specifically working throughthe ppar receptors. that’s p-p-a-r gamma receptors. if you’re familiar with ketones, they’reworking through the ppar alpha receptors that

are on the nuclear membrane. the ppar gamma are also working there, andthey are changing the enzymes and the activated genes that are producing enzymes as well assome of the proteins that are being produced in the body. it’s that control point, the nucleus, inshifting the genetic makeup. that’s how also that cbd orchestrates someof the changes in the enhancement of the endocannabinoid system, by affecting those genes that areinvolved with improving the endocannabinoid system but also those other measures, turningoff those bad genes, particularly the oncologic genes that are there as well.

dr. pompa:is there a length of time in any of these studies that people staying on cbd saw thebenefit of the gene expression? dr. blair:i don’t have any of the studies. i can’t quote anything of that factor. in terms of clinical experience, what i’veseen is that two to three months out, people are able to dramatically reduce their dosageso they’re not having to use high levels, and they’re getting sustained benefits. they’re not having a falling back into theirprevious states. i think that’s an indication that some ofthese things are going on, but we certainly

don’t have the evidence at this point. this is such a fledgling science that’sgoing on. dr. pompa:no doubt about it. on the dosing again, i know that the 18%,the one that we have, the syringe-looking one, it has pumps, which is nice. remember the old days. i don’t want to bring up the old days. every pump, it delivers a nice 15 mg dose. it makes it a lot easier to take a dose inthe morning and a dose later.

that’s where i start as well. i typically start someone with one squirtof that twice a day. what about the higher-end doses? dr. blair:that’s a great way to start in the x-pen that you’re talking about. i just want to make one correction there. the old product that first came out from elixinolwas a syringe, very much syringe style. that was 18%. the new product is actually only 10%.

it had to be reduced because it was too thick. you remember, there may have been some difficultiesin terms of squeezing it out. in order to make that delivery system consistent,it has been reduced in terms of viscosity so that it can be easily expressed and deliverthat 15 mg. the x-pen is a great device, and i think it’sthe premiere device and product that elixinol offers because it delivers a full blend ofthe natural cannabinoids as well as the terpenes and flavonoids that go along with it. exactly, i think the x-pen is probably thepremiere. it’s got some supplemental cannabinoidsthat are there.

not endocannabinoids, that’s only insideof us, but it has actually some extra cannabinoids that are not psychoactive whatsoever but reallyenhance the effectiveness of the cannabidiol dr. pompa:starting with one pump, it’s one squirt of that. there’s your 15 mg, and you do that twicea day, great starting point. where do we go from there? someone says okay, i want more. i have als or i have a condition that i thinkmight demand more. pain might demand more, right?

where do you go from there on the high end? dr. blair:i think you just increase the dose. you increase it very quickly. i haven’t seen any reason to wait. if you have any toxicity or adversity thengo ahead and double the dose. get to the point where you’re getting aresolution of some of those symptoms that are really bothering you. if it’s pain and you need analgesia or it’sanxiety, increase the dose until you get that effectiveness.

that can be just in a day, or two days, orthree days. you don’t have to wait a long time as ifyou would with an antidepressant. dr. pompa:i always tell them to keep it under their tongue as long as they can. that gets a little bit difficult, but what’syour recommendations there? we want full absorption maximum dose. dr. blair:i think that under the tongue and what i call transmucosal absorption is some of the best. that means that it’s absorbed anywhere inthe mouth.

the back of the tongue may be the best. under the tongue is very effective, but tohold it in the mouth is great because you get the direct absorption. when you get direct absorption through themucous membranes, you’re bypassing the metabolic effects, the first pass effects, of the liver. you’re getting immediate penetration intothe blood stream, to the brain, and to the tissues throughout the body. i think that’s an excellent approach. how long?

it’s whatever you can really tolerate, whetherthat’s two minutes or if it’s five minutes. you’re going to swallow it after, and it’sgoing to get well-absorbed through that particular system, so you’re not going to have anydifficulty with it. it just takes a little bit longer to reacheffectiveness when you swallow it, let’s say a capsule, where it has to go into thegi tract versus you taking the x-pen and you’re swishing that in your mouth. i don’t have them hold it under the tongue. i have them swish it in the mouth becausei really want to get the absorption all over the mouth.

you know, daniel, you can use that. it’s any membrane. if somebody wants to use it rectally, it’svery possible to use it. you can have special suppositories made, butit doesn’t have to be that way. you can actually use the capsules directlyinto the rectum without any difficulty. dr. pompa:let’s talk about some of their other sources because i think we carry as well, or at leastrevelation health does, they have the tinctures which is a lower dose. it tastes better.

let’s talk about how that would be a benefit. they also have it in capsules, so you mentioneda few things there. talk a little bit about that. dr. blair:the capsules are great because they – that fits in with our current paradigm in termsof taking pills and taking capsules. this is truly for a healthful substance. each capsule is 15 mg, so it matches the x-penin terms of the dose. the standard that i recommend is 15 mg, onecapsule twice a day. that’s what the bottle is.

it’s 60 capsules. that’s got a nice blend of the other cannabinoidsand the flavonoids so really valuable product. then we step down to the tinctures which havedifferent concentrations. you’ve got the 100 mg bottle that has about3 mg per ml. then you’ve got the 300 mg bottle that has10 mg per ml. then the 3,600 has 30 mg per ml. you’re getting pretty high concentrationsof 3% in the 3,600 product. when you’re looking for longevity and you’regoing to be looking at continuing this, this is a great item to get because you can reallymaintain your health.

you don’t have to worry about reorderingor having enough. if you’ve got a 3,600 mg which has 120 ml,it’ll last for quite a while in most cases depending on what the dosage is. meredith:now dr. pompa, you often suggest taking the cbd using with a fat, right? perhaps some mct oil, some coconut oil, andthat would increase the absorption, right? dr. pompa:they mixed the product up. before, it was a little different. now, like doc’s pointing out here, they’vemade this product in a combination of different

things. doc, back in the day, we were mixing withdifferent things to help the absorption. they’ve really solved that. elixinol made it a lot easier that you don’thave to do that as much. dr. blair:right, and i do agree with you, daniel, in terms of using a fatty food or a fatty mealafterwards is excellent because we’re talking about the same sort of absorption process. we’re talking about activating the lipidsystem and the fat. i don’t think that’s any problem for youguys and the network because they’re all

into and realize how important healthy fatsare in the body. that’s really important. realizing that that’s not for everybodyand not everybody can do that, the elixinol has made a new product called liposomes. these are actually water soluble. because they’re water soluble and they’rewrapped with a phosphate skin, they’re more absorbable. they have a better bioavailability than thetinctures. you can get sometimes five or even ten timesthe effectiveness using the liposomes as you

do get with the tinctures or some of the otherformats. meredith:do you guys carry any topical products? what do you think of the topical or the transdermalabsorption of cbd? dr. blair:we have just come out with a healing cream, a healing balm, that can be used on the skin. it’s got great effects. it’s a wonderful application that can goon irritated areas containing a modest amount of cannabidiol to get that absorption. i have to tell you one thing.

you look back at flax, and flax bandages werewhat people generally used in europe and in different wars. flax actually contains some cannabidiol ofitself which may account for the extra healing effects that have occurred with that. topical is very true. generally, i recommend that you can use eitherthe liposomes or you can use the tinctures as a topical application. i recommend it for rashes of all kinds, whetherthat’s just irritation, or it’s viral infections, or it’s trauma where you haveincurred some injury and damage.

in those cases, i’ve seen advanced and acceleratedhealing for large wounds as well as analgesia to take care of it. not too long ago, i was not paying attention,didn’t put my cup of my hot tea down properly, and i burned my lip on it. i immediately put the cbd on it. it just absolutely quenched the pain and discomfortas well as preventing any blister formation. it’s great for the medicine cabinet andfor those injuries that we have along the way. dr. pompa:i think our viewers are right now are probably

going yes, i want to try it, but i don’tknow where to start. we talked about the x-pen, and we talked aboutthe tinctures, and we talked about liposomes. then we talked about transdermal flax. kind of give our viewers where do i start? what are the benefits of the tinctures, theliposomes? when do i do which one? i know they’re going to ask the question. meredith, we’re going to get that question. i’m trying to nip it in the bud for you.

dr. blair:let me get that taken care of, but i just want to go back to one of the first questionsyou had is, meredith, you said i have to take a whole lot of this. what’s going on? why do i have to take a whole lot? i’ve encountered patients who have not respondedat all. one of the things that will not allow youto respond to the phytocannabinoids and cbd specifically is a lack of omega-3 fats withinthe body. if you’re deficient in omega-3s then – theomega-3s, they work by creating a lot of the

receptors and a lot of the hormones that arepart of the endocannabinoid system. if you don’t have those omega-3s in theproper balance or if you’re overwhelmed with omega-6s, then you’re not going tobe able to have the playing field that cannabidiol can work on and can activate in the endocannabinoidsystem. whenever i encounter people who are less thanan ideal response, i want to make sure they’re getting adequate omega-3s within their system. that’s one of those caveats. i wanted to make sure that you got that messagein there. now, are you deficient, meredith, in omega-3s?

probably not. it’s just is probably your individuality. because we’re all individuals, what’sthe best for anybody? in my looking at it, you want to look at thoseother things. you want a whole body approach. you want a whole person approach. it is diet. it is exercise. it is sleep.

you’ve got to take care of those. the phytocannabinoids, the cannabidiol isthere for that enhancement taking it up to the next level to get them recovered or gettheir symptoms controlled right away. then, what is the product, what is the routethat they would be most comfortable with? if we’re talking about people who are reallyused to the standard paradigm of pills and capsules, then the capsules are a great wayto go to get them started with it. if you have to make fine-tuning adjustments,though, you’ve got to think in terms of tinctures where you can adjust the dosage. you can use the dropper to figure out howmany milliliters or fractions of a milliliter

that you want to do to get the exact dosethat you’re using. if you want something real quick and easy,then the x-pen delivering one shot of the cbd into the mouth. for kids and young people or people who havereally terrible, difficult taste concerns like autistics. they have a real problem with taste. the liposomes are a great place to start withthem because they’re a very attractive taste. they’re flavorful, and they can mix withwater or they can mix with other substances, and they can easy to get into people to havethem use.

any of these things can be used depending– and what is the best one? the best one is the one that they’ll use. the best exercise is the one that people willdo. you’ve got to integrate it into their particularlifestyle. let me just point out one thing on the liposomes. because of their increased bioavailability,i generally recommend – i have a typical standard that i recommend. i reduce that. i find that the liposomes are about five timesmore potent in most people and so you don’t

need to take as much. in some people, they’re just not as effectiveas the tinctures, or the x-pen, or the capsules. they’re very, very good, and they’re veryeffective especially for behavioral issues and anxiety but sometimes not as effectivefor the chronic pain and for the high doses that you might require. in terms of topical dose, your fallback positionis always – if people really can’t stand the taste, and they really have difficulty,or they think there’s some problem that they’re developing as a result of usingan oral formulation, put it on the skin. have them get some absorption through theback of the hand, or on the abdomen, or the

back. my wife has some pain issues, and i use someapplications onto her back. it’s very, very effective for systemic absorptionas well as using topical relief of some aches and pains. when i get a shoulder pain or a knee pain,i use it there. i get systemic absorption. that’s pretty clear. maybe not as much as an oral dose, but it’seffective. dr. pompa:i have just a quick question.

we’re coming at the top of the hour here,but why if the liposome was five times more potent as far as absorption because it’ssurrounded by a fat molecule, why would it be less effective for some of the other conditions? dr. blair:i can’t answer that. it’s wrapped by a phosphate molecule, andthe phosphate makes it more bioavailable as a result of that: better absorption, bettertransmission and absorption through the gut. i don’t know what that is. we don’t understand that exactly. we do know that it’s better absorbed andmaybe the other formulations are having difficulty

going across the membrane. they’re get metabolized more quickly. something within that process that is interferingwith the delivery and the bioavailability. if we can get it in then it’s more effectivethat way. dr. pompa:maybe i misunderstood. i thought you said the liposome was five timesmore potent. however, it didn’t work as well as someof the other deliveries with certain conditions. dr. blair:that’s right. that’s exactly so.

where did i lead you astray? dr. pompa:maybe i’m mixed up. meredith, make us both clear. meredith:i don’t know. i wasn’t really following that very clearly. dr. blair:let me reiterate, then. what i see with the liposomes is it’s gotimproved bioavailability so it appears to be more potent. when you take in one pump, which is one milligramof the liposome 300, then it’s like taking

5 mg of the tincture. why wouldn’t you just say well, just letme stick with the liposomes. i can get five times the effect with it. that works in many people, but it doesn’twork in everybody. what i find is that the x-pen is better. it’s got a better blend and a balance ofthe other cannabinoids and the other substances. same is true for the capsule. the tincture also has a little bit more. the liposomes are your bare bones cannabidiol.

you don’t get a lot of the extra thingsthat go along with it. it may be the other extra things that aremissing. dr. pompa:that’s it. you answered it, right? because the other factors aren’t there,it’s just straight cbd. although better delivered, it doesn’t havesome of the extra factors as would the x-pen or the tinctures. i got it. meredith:--different tools, too, because as we know,

everyone reacts differently to different things. some work better for some than others. the tools and just all the options are wonderfulto have. dr. blair:that’s great. here, you have the flexibility of doing whatyou need to and making adjustments. rather than one size fits all, it’s a matterof customizing for that individual’s need. along with your other therapies, i don’twant to deemphasize those at all. i want to really make a point that those othertherapies are also important for the long-term, whole-person concept.

dr. pompa:we preach and i teach a multitherapeutic approach. why people are getting sick is, yeah, certaingenes are getting turned on. certain stressors, toxins included, are turningon those genes. then we have a disruption in the microbiometoday that’s making this whole thing a perfect storm. if we’re not working in all of those areastogether with the multitherapeutic approach, we’re not going to get well today. we’re not. we’re not going to function in good health.

it is everything. this is a tool that me and my doctors, weabsolutely love. i think you brought more clarity, at least,to our viewers as far as how to use these tools. dr. blair:i brought some resources, too. meredith, i don’t know if it’s possibleif you could show some of those references. here’s a collection about the endocannabinoidsystem and the clinical endocannabinoid deficiency syndrome that we are seeing. these are excellent.

these are full articles that you can downloadand you can see and review. i really welcome you to take a look at theseand find out what those sources and take a read on these articles. i found them fascinating, but i find thatany of these studies on endocannabinoid system as well as cannabidiol are quite remarkable. it’s going to fulfill my many years, i’mabsolutely convinced. thank you for that because i’m no doubtcertain that it’s resources that everybody needs to look at, so thank you. dr. blair:also, with you, daniel, in terms of what you’re

doing and in terms of the whole-person conceptand restoring balance to the body, and the cellular healing, that’s very critical,as well. you have to have all of your major pointshave to be addressed if you’re going to get maintained health and restoration of health. dr. pompa:absolutely. we always enjoy having you on, doc. there is no doubt about it. we appreciate you coming on, always a wealthof knowledge especially in this area. i know it’s one of your loves.

you research a lot of things, and you arean absolute wealth of knowledge in this area, that’s for sure. dr. blair:i sure appreciate the opportunity to share this because i think it’s so critical andunrecognized in all of our health professionals that we can integrate all of these approaches. as an integrated approach, it’s a wonderfulway. it also combines all of us as medical professionalsalong the same line using the same system for the benefit of others. dr. pompa:thank you.

meredith:awesome. thank you, dr. pompa, and thank you, dr. blair,for sharing all of this amazing information with us. dr. blair gave us permission to upload thispowerpoint, as well, with some of the highlights of what we talked about, all of those resources,as well, that you can check out. that’s going to be on podcast.drpompa.comon the podcast page along with the full transcript of this episode. in closing, thank you so much, everyone. thanks for watching, have a great weekend,and we’ll see you next time.

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