hold the flexhaler upright, twist the cover and lift it off. twist the brown grip in one direction as far as it will go. twist the grip fully back again in another direction. you will hear a click. breathe out completely away from the flexhaler. place the mouthpiece in your mouth and breathe in quickly and deeply, while holding the flexhaler in a horizontal position. remove the mouthpiece, hold your breath for 10 seconds or as long as you are comfortable and breathe out slowly through mouth or nose. repeat steps 2 to 6 after 30 seconds, if you have to take another puff. replace the cap.